Guthrie was born in Fort Sill, Oklahoma to US Army General John R. and Mrs. Rebecca J. Guthrie. He graduated in 1975 from the University of Virginia with a Bachelors of Science in Education and received a Masters in Education from the school in 1976. After spending the majority of his working career as a Realtor in Northern Virginia, he moved back to Charlottesville to become President & CEO of the Roy Wheeler company. 
Guthrie and his wife Dottie were married in 1978 and they have three children. 
- Web. [tt_news=78&tx_ttnews[backPid]=6&cHash=7efe5c9ef69721c56ca11b90d58d24c4 Michael Guthrie, Roy Wheeler Realty CEO, is named Chamber 2011 Small Business Person of the Year at Chamber's Aunnual Spring Business Luncheon], Charlottesville Regional Chamber of Commerce, retrieved June 6, 2011.