The Junior League of Charlottesville established the center in 1960 in order to provide educational and enrichment activities for people over the age of 50. The facility was the second of its kind in Virginia.
The Senior Center first operated in rented space at 301 East Market Street before quickly moving to another rented space at 101 East High Street. In 1963, the agency became independent of the Junior League. In 1982, the Center moved into the Central Library on Market Street, a space it occupied until the Jessup family made space near their Pepsi Cola bottling facility available at half-price. The new 17,000 square foot facility on Pepsi Place opened on September 11, 1991.
In November 2002, the Senior Center became accredited by the National Institute of Senior Centers, the first such facility in Virginia to receive that designation.
New facility search
Officials at the Senior Center have spent several years looking for a new home. One candidate was a building owned by ACAC that is the former home of the Charlottesville Day School. The Albemarle County Planning Commission granted a special-use permit for the Senior Center to occupy the space, though Center officials opted not to move there. 
In October 2012, Senior Center officials announced they would move into a new facility in the Belvedere development in Albemarle County. They said they hoped to raise $18 million over the next three years to build the $20 million facility. If built, the Center at Belvedere will contain an indoor walking track, a gymnasium, a library and an auditorium. 
Board of Directors (2016-2017)
- Hi Ewald, President
- Greg Menke, Vice president
- Rene Bond, Secretary
- Dick Brownlee, Treasurer
- Elizabeth D. Beasley
- Joe Gieck
- Michael Guthrie
- Rob Jiranek
- Jennifer King
- Mike Kirkman
- Joe Krenn
- Jeanne McCusker
- Ann Myer
- Virginia Tahboub
- Douglas Wheeler
- "History of the Senior Center Inc." Welcome to the Senior Center. Web. 16 Dec. 2009. <http://seniorcenterinc.org/about/history.shtml>.
- Tubbs, Sean J. "Planning Commission approves potential new site for Senior Center; Charlottesville Day School would need new home." Charlottesville Tomorrow News Center. Web. 15 Dec. 2009. <http://cvilletomorrow.typepad.com/charlottesville_tomorrow_/2009/07/senior_center_relocation.html>.
- Web. Senior Center unveils plans for new, larger facility, Aaron Richardson, Daily Progress, World Media Enterprises, October 9, 2012, retrieved October 17, 2012.
- Web. More than $500,000 in grants awarded, Daily Progress, World Media Enterprises, December 15, 2010, retrieved December 15, 2010.